Urate metabolic process

Across TCGA patient cohorts, RNA activity of the Urate metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FKBP9, C1R, and C1S, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Urate metabolic process activity versus FKBP9 in UCEC (Pearson r = -0.41).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FKBP9 →	-0.482	-0.115	<.001	<.001	3	6
OV	C1R →	-0.618	-0.060	<.001	<.001	3	5
OV	C1S →	-0.497	-0.054	.001	.003	3	5
BRCA	DCN →	-0.809	-0.062	<.001	<.001	3	5
OV	DOCK11 →	-0.422	-0.065	.002	<.001	3	5
OV	HMCN1 →	-0.986	-0.099	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046415 vs FKBP9 — UCEC

Explore this scatter interactively →