Urate metabolic process

Across TCGA cell cohorts, RNA activity of the Urate metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are COA8, SUCLG1, and MARCHF3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, COA8 grouped by Urate metabolic process-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	COA8 →	-0.692	-1.339	.004	<.001	2	6
PANCREAS	SUCLG1 →	+0.776	+1.700	<.001	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	MARCHF3 →	-1.275	-1.157	.004	.005	3	4
PANCREAS	EIF3J →	+0.859	+1.451	.001	.002	3	3
PANCREAS	TMEM19 →	+1.645	+1.671	<.001	.001	3	3
PANCREAS	C2CD2 →	-0.611	-1.408	.005	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

COA8 by Urate metabolic process activity — LUNG_SCLC

Explore this box plot interactively →