Urate metabolic process

Across TCGA cell cohorts, RNA activity of the Urate metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPH3AL, CRYBB2, and TBC1D2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Urate metabolic process activity versus RPH3AL in STOMACH (Pearson r = 0.63).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	RPH3AL →	+1.669	+1.506	<.001	<.001	3	4
OVARY	CRYBB2 →	-0.178	-1.488	.006	.001	3	4
LUNG_SCLC	TBC1D2 →	-0.938	-0.910	.002	.003	3	4
STOMACH	ANKRD1 →	-3.456	-1.590	<.001	<.001	3	4
STOMACH	HOXA10 →	+2.503	+1.506	.002	<.001	3	4
BREAST	CTSC →	+2.064	+0.988	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046415 vs RPH3AL — STOMACH

Explore this scatter interactively →