5-phosphoribose 1-diphosphate metabolic process

Across TCGA patient cohorts, RNA activity of the 5-phosphoribose 1-diphosphate metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CHD3_S1605, CD82, and CHD3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, 5-phosphoribose 1-diphosphate metabolic process activity versus CHD3_S1605 in HNSC (Pearson r = 0.38).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	CHD3_S1605 →	+0.369	+0.062	.002	.004	3	6
PDAC	CD82 →	-0.475	-0.035	.002	.002	3	6
LSCC	CHD3 →	+0.301	+0.044	<.001	<.001	3	6
LSCC	PRPSAP2 →	+0.344	+0.070	<.001	<.001	3	6
HNSC	CHD3_T1569 →	+0.431	+0.085	<.001	<.001	3	5
HNSC	ALG1 →	-0.292	-0.098	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046391 vs CHD3_S1605 — HNSC

Explore this scatter interactively →