5-phosphoribose 1-diphosphate metabolic process

Across TCGA patient cohorts, RNA activity of the 5-phosphoribose 1-diphosphate metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CSF3R, SAMD12, and LRRK2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, 5-phosphoribose 1-diphosphate metabolic process activity versus CSF3R in PDAC (Pearson r = -0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	CSF3R →	-0.907	-0.241	<.001	<.001	3	4
PDAC	SAMD12 →	+0.363	+0.155	.009	.009	3	4
BRCA	LRRK2 →	-0.602	-0.108	<.001	<.001	3	4
COAD	HCAR3 →	-0.905	-0.107	.002	<.001	3	4
COAD	CASS4 →	-0.586	-0.167	<.001	<.001	3	4
COAD	HCAR2 →	-1.108	-0.125	.007	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046391 vs CSF3R — PDAC

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