5-phosphoribose 1-diphosphate metabolic process

Across TCGA cell cohorts, RNA activity of the 5-phosphoribose 1-diphosphate metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRPSAP2, IQCB1, and LRBA, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, 5-phosphoribose 1-diphosphate metabolic process activity versus PRPSAP2 in BLOOD_Lymphoma (Pearson r = 0.58).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	PRPSAP2 →	+1.224	+0.942	<.001	<.001	3	5
BLOOD_Lymphoma	IQCB1 →	+0.907	+1.044	<.001	<.001	3	4
BLOOD_Lymphoma	LRBA →	+1.089	+0.874	.004	.004	3	4
BLOOD_Myeloma	TAS2R30 →	+0.081	+1.478	.002	.001	3	4
BLOOD_Leukemia	MAP3K9 →	+1.082	+0.726	.001	<.001	3	4
BLOOD_Leukemia	SNTA1 →	+2.160	+0.904	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046391 vs PRPSAP2 — BLOOD_Lymphoma

Explore this scatter interactively →