Monosaccharide catabolic process

Across TCGA patient cohorts, RNA activity of the Monosaccharide catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SMARCC2_T322, TKFC, and DOCK4_S1620, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Monosaccharide catabolic process activity versus SMARCC2_T322 in GBM (Pearson r = -0.23).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SMARCC2_T322 →	-0.712	-0.029	.002	.005	3	4
COAD	TKFC →	+0.231	+0.017	.003	<.001	3	4
UCEC	DOCK4_S1620 →	-0.903	-0.100	<.001	<.001	3	4
CCRCC	GALM →	+0.292	+0.032	.001	.001	3	4
GBM	GBA →	+0.312	+0.044	.009	<.001	3	4
GBM	PKM_S249 →	+0.387	+0.019	.002	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046365 vs SMARCC2_T322 — GBM

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