Monosaccharide biosynthetic process

Across TCGA patient cohorts, RNA activity of the Monosaccharide biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CXCL1, GALR1, and H2BC13, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Monosaccharide biosynthetic process activity versus CXCL1 in OV (Pearson r = -0.09).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	CXCL1 →	-1.838	-0.193	<.001	<.001	3	4
PDAC	GALR1 →	+0.090	+0.089	<.001	<.001	3	4
CCRCC	H2BC13 →	-0.645	-0.145	.005	.003	3	4
CCRCC	PRAL →	-0.218	-0.126	<.001	.001	3	4
UCEC	PMAIP1 →	-0.953	-0.170	.003	.003	1	5
LSCC	RNU7-141P →	+1.175	+0.117	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046364 vs CXCL1 — OV

Explore this scatter interactively →