Diacylglycerol catabolic process

Across TCGA cell cohorts, RNA activity of the Diacylglycerol catabolic process pathway is significantly associated with the shRNA dependency of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAT2A, RHBDF1, and WDR74, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MAT2A grouped by Diacylglycerol catabolic process-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	MAT2A →	-0.325	-1.089	<.001	<.001	3	3
OVARY	RHBDF1 →	-0.240	-1.030	.003	<.001	3	3
BLOOD_Lymphoma	WDR74 →	-0.486	-0.271	.001	<.001	3	3
BLOOD_Leukemia	XPO4 →	-0.226	-0.219	.006	<.001	3	3
LARGE_INTESTINE	PRKCE →	-0.165	-0.118	.007	.004	3	3
LARGE_INTESTINE	MLLT3 →	-0.134	-0.096	.007	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MAT2A by Diacylglycerol catabolic process activity — OVARY

Explore this box plot interactively →