Diacylglycerol metabolic process

Across TCGA cell cohorts, RNA activity of the Diacylglycerol metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DAGLB, CYTH3, and TPX2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Diacylglycerol metabolic process activity versus DAGLB in BLOOD_Leukemia (Pearson r = 0.59).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	DAGLB →	+1.775	+1.217	<.001	<.001	3	5
LUNG_SCLC	CYTH3 →	+0.880	+0.616	.005	.006	3	4
PANCREAS	TPX2 →	+0.958	+0.352	.006	.007	3	4
BLOOD_Leukemia	ARL2 →	-0.804	-0.690	.002	.008	3	3
LARGE_INTESTINE	ZNF132 →	-0.795	-0.416	.005	.007	3	3
BLOOD_Lymphoma	LYL1 →	+4.055	+0.463	.005	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046339 vs DAGLB — BLOOD_Leukemia

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