Positive regulation of JNK cascade

Across TCGA cell cohorts, RNA activity of the Positive regulation of JNK cascade pathway is significantly associated with the shRNA dependency of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MLEC, SCN3B, and KCNC3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MLEC grouped by Positive regulation of JNK cascade-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	MLEC →	+0.300	+0.109	<.001	.001	3	4
BLOOD_Leukemia	SCN3B →	+0.230	+0.042	.003	.007	3	4
BLOOD_Myeloma	KCNC3 →	+0.412	+0.045	.001	.002	3	4
OVARY	PACSIN2 →	+0.273	+0.055	.003	<.001	3	4
LUNG_SCLC	KDM1A →	+0.382	+0.055	<.001	<.001	3	4
LARGE_INTESTINE	CRIM1 →	+0.159	+0.031	.009	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MLEC by Positive regulation of JNK cascade activity — BONE

Explore this box plot interactively →