Negative regulation of JNK cascade

Across TCGA cell cohorts, RNA activity of the Negative regulation of JNK cascade pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GAL3ST4, IL27RA, and ARHGEF6, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GAL3ST4 grouped by Negative regulation of JNK cascade-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	GAL3ST4 →	+1.661	+0.243	.001	<.001	3	5
SOFT_TISSUE	IL27RA →	-2.304	-0.339	<.001	<.001	3	4
SOFT_TISSUE	ARHGEF6 →	+2.635	+0.239	.001	.008	3	4
OVARY	GMPS →	-0.569	-0.230	.003	.005	3	4
OESOPHAGUS	KIF9 →	-0.986	-0.234	.007	.001	3	4
URINARY_TRACT	PELI2 →	+2.099	+0.380	.009	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GAL3ST4 by Negative regulation of JNK cascade activity — SKIN

Explore this box plot interactively →