Regulation of JNK cascade

Across TCGA patient cohorts, RNA activity of the Regulation of JNK cascade pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IMPDH1P8, SLAMF6, and RN7SL172P, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of JNK cascade activity versus IMPDH1P8 in PDAC (Pearson r = -0.13).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	IMPDH1P8 →	-0.214	-0.378	.009	.001	3	3
BRCA	SLAMF6 →	+0.822	+0.556	.007	.001	2	4
BRCA	RN7SL172P →	+0.362	+0.567	.001	.001	3	3
COAD	CFTR-AS1 →	-0.748	-0.261	<.001	.004	3	3
HNSC	LIN28B →	-1.386	-0.781	.001	.002	3	2
HNSC	RAB1AP2 →	-0.617	-0.691	.007	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046328 vs IMPDH1P8 — PDAC

Explore this scatter interactively →