Regulation of JNK cascade

Across TCGA cell cohorts, RNA activity of the Regulation of JNK cascade pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PIM1, STRIP1, and METTL21A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of JNK cascade activity versus PIM1 in URINARY_TRACT (Pearson r = -0.73).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	PIM1 →	-1.871	-1.159	<.001	<.001	3	4
BREAST	STRIP1 →	-0.815	-0.622	.001	.006	3	4
UPPER_AERODIGESTIVE_TRACT	METTL21A →	+1.095	+1.216	<.001	<.001	3	4
OVARY	GABARAPL2 →	+0.615	+0.995	.002	<.001	3	4
BLOOD_Leukemia	SMAD5 →	-0.929	-0.234	.002	<.001	3	4
LIVER	HLF →	-2.054	-1.239	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046328 vs PIM1 — URINARY_TRACT

Explore this scatter interactively →