Positive regulation of glucose import

Across TCGA patient cohorts, RNA activity of the Positive regulation of glucose import pathway is significantly associated with the RNA expression of multiple genes, with the CHOL cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZBED6, RBL2, and USP34, each associated with the pathway in up to 31 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of glucose import activity versus ZBED6 in CHOL (Pearson r = 0.66).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CHOL	ZBED6 →	+1.894	+0.071	<.001	<.001	3	31
UVM	RBL2 →	+1.236	+0.034	<.001	<.001	3	30
DLBC	USP34 →	+1.668	+0.048	.001	.005	3	30
ACC	PRKAB2 →	+1.678	+0.059	<.001	<.001	3	30
UVM	ZFC3H1 →	+1.264	+0.036	<.001	<.001	3	30
UVM	DMXL1 →	+1.221	+0.033	<.001	<.001	3	30

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046326 vs ZBED6 — CHOL

Explore this scatter interactively →