Positive regulation of glucose import

Across TCGA patient cohorts, RNA activity of the Positive regulation of glucose import pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IRS2, AKAP12, and LMOD1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of glucose import activity versus IRS2 in LSCC (Pearson r = 0.36).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	IRS2 →	+1.177	+0.808	<.001	<.001	3	9
UCEC	AKAP12 →	+0.826	+0.648	.007	.001	3	7
UCEC	LMOD1 →	+1.174	+0.590	<.001	<.001	3	7
UCEC	MSRB3 →	+1.111	+0.626	<.001	<.001	3	7
UCEC	CSRP1 →	+1.001	+0.695	<.001	.001	3	6
COAD	HSPB7 →	+0.922	+0.965	.008	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046326 vs IRS2 — LSCC

Explore this scatter interactively →