Positive regulation of glucose import

Across TCGA cell cohorts, RNA activity of the Positive regulation of glucose import pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NLRC3, SIRT4, and ASTN2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of glucose import activity versus NLRC3 in BLOOD_Leukemia (Pearson r = 0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	NLRC3 →	+1.398	+0.879	.003	<.001	3	4
OESOPHAGUS	SIRT4 →	+0.957	+0.454	.005	.005	3	4
LIVER	ASTN2 →	+0.940	+0.441	.003	.005	3	3
LIVER	PBX1 →	-2.265	-0.352	.006	.005	3	3
KIDNEY	TP53INP1 →	+2.127	+0.476	.002	.007	3	3
KIDNEY	APBB1 →	+2.327	+0.384	.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046326 vs NLRC3 — BLOOD_Leukemia

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