Negative regulation of glucose import

Across TCGA patient cohorts, RNA activity of the Negative regulation of glucose import pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SYNPO_S833, SEPTIN2, and SSC5D, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of glucose import activity versus SYNPO_S833 in LSCC (Pearson r = 0.44).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SYNPO_S833 →	+0.756	+0.081	.001	<.001	3	5
BRCA	SEPTIN2 →	+0.191	+0.038	.005	.008	3	5
BRCA	SSC5D →	+0.662	+0.046	<.001	<.001	3	5
BRCA	THBS3 →	+0.438	+0.045	.003	<.001	3	5
BRCA	TNS2 →	+0.275	+0.035	.002	.002	3	5
BRCA	COL6A2 →	+0.466	+0.043	.002	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046325 vs SYNPO_S833 — LSCC

Explore this scatter interactively →