Negative regulation of glucose import

Across TCGA patient cohorts, RNA activity of the Negative regulation of glucose import pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AKR1C2, LBP, and STAMBPL1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of glucose import activity versus AKR1C2 in BRCA (Pearson r = 0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	AKR1C2 →	+1.264	+0.206	<.001	<.001	3	4
BRCA	LBP →	+1.318	+0.201	.003	<.001	3	3
OV	STAMBPL1 →	+0.444	+0.190	.005	.002	3	3
BRCA	TGFBR2 →	+0.662	+0.264	.006	.002	3	3
BRCA	PRKD1 →	+0.605	+0.288	.001	<.001	3	3
BRCA	C14orf132 →	+0.811	+0.217	.004	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046325 vs AKR1C2 — BRCA

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