Regulation of glucose import

Across TCGA patient cohorts, RNA activity of the Regulation of glucose import pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NEGR1, UTRN, and CSRP1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of glucose import activity versus NEGR1 in BRCA (Pearson r = 0.35).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	NEGR1 →	+0.633	+0.028	<.001	.001	3	8
UCEC	UTRN →	+0.312	+0.050	.001	.001	3	8
UCEC	CSRP1 →	+1.053	+0.049	<.001	<.001	3	8
BRCA	DDAH2 →	+0.508	+0.034	<.001	<.001	3	8
UCEC	LTBP2 →	+0.788	+0.054	<.001	<.001	3	8
UCEC	SORBS1 →	+1.093	+0.056	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046324 vs NEGR1 — BRCA

Explore this scatter interactively →