Regulation of glucose import

Across TCGA patient cohorts, RNA activity of the Regulation of glucose import pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LMOD1, AOC3, and LRRN4CL, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of glucose import activity versus LMOD1 in UCEC (Pearson r = 0.48).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	LMOD1 →	+1.879	+0.768	<.001	<.001	3	9
UCEC	AOC3 →	+1.200	+0.790	<.001	<.001	3	7
UCEC	LRRN4CL →	+1.067	+0.546	<.001	.006	3	7
UCEC	PLN →	+1.438	+0.767	<.001	<.001	3	7
BRCA	IRS2 →	+0.952	+0.719	<.001	<.001	3	6
UCEC	MYH11 →	+2.200	+0.811	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046324 vs LMOD1 — UCEC

Explore this scatter interactively →