Regulation of glucose import

Across TCGA cell cohorts, RNA activity of the Regulation of glucose import pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TUBA1A, PEA15, and TBC1D20, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of glucose import activity versus TUBA1A in SKIN (Pearson r = 0.55).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	TUBA1A →	+1.340	+0.265	.009	.006	3	7
CNS	PEA15 →	+1.242	+0.282	<.001	<.001	3	6
STOMACH	TBC1D20 →	+0.957	+0.887	.001	.008	3	5
STOMACH	MYO5A →	+2.791	+0.530	<.001	<.001	3	5
LUNG_SCLC	TAF9B →	+0.638	+0.221	.001	.006	3	5
LARGE_INTESTINE	ARHGEF17 →	+1.498	+0.313	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046324 vs TUBA1A — SKIN

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