Phenol-containing compound biosynthetic process

Across TCGA patient cohorts, RNA activity of the Phenol-containing compound biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are C1orf43, KLF16_S99, and BTAF1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Phenol-containing compound biosynthetic process activity versus C1orf43 in BRCA (Pearson r = 0.15).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	C1orf43 →	+0.291	+0.453	<.001	.002	3	3
GBM	KLF16_S99 →	-0.989	-0.713	<.001	<.001	3	3
LSCC	BTAF1 →	-0.172	-0.670	.002	.002	3	3
PDAC	RNF40_T557 →	-0.693	-1.192	<.001	<.001	3	2
PDAC	SAMD4B_S626 →	-1.137	-0.977	<.001	<.001	3	2
LSCC	SETD2_S744 →	-0.601	-0.895	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046189 vs C1orf43 — BRCA

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