Aldehyde catabolic process

Across TCGA patient cohorts, RNA activity of the Aldehyde catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ALDH2, HAGH, and SPTBN1_S257, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Aldehyde catabolic process activity versus ALDH2 in BRCA (Pearson r = 0.49).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ALDH2 →	+0.704	+0.054	<.001	<.001	3	9
OV	HAGH →	+0.371	+0.060	.001	.006	2	9
LSCC	SPTBN1_S257 →	+0.640	+0.109	<.001	<.001	3	6
COAD	GGH →	-0.869	-0.053	<.001	<.001	3	6
PDAC	PLIN4 →	+0.891	+0.056	.004	.001	3	6
LSCC	PYGM →	+0.398	+0.071	<.001	.003	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046185 vs ALDH2 — BRCA

Explore this scatter interactively →