Aldehyde catabolic process

Across TCGA patient cohorts, RNA activity of the Aldehyde catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PNKD, RPAP1_S80, and SUPT6H_T1523, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Aldehyde catabolic process activity versus PNKD in BRCA (Pearson r = 0.37).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PNKD →	+0.337	+0.066	<.001	.002	3	4
GBM	RPAP1_S80 →	+1.013	+0.106	<.001	<.001	3	3
OV	SUPT6H_T1523 →	+0.517	+0.122	<.001	<.001	3	3
LSCC	DSP_S2608 →	-1.366	-0.207	<.001	.001	3	3
COAD	GIT1_T480 →	-0.527	-0.133	<.001	.003	3	3
OV	IL6ST_S667 →	+0.795	+0.239	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046185 vs PNKD — BRCA

Explore this scatter interactively →