Aldehyde catabolic process

Across TCGA cell cohorts, RNA activity of the Aldehyde catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ACO1, RALA, and DNMBP, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ACO1 grouped by Aldehyde catabolic process-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	ACO1 →	-1.086	-0.828	.002	.001	3	5
BONE	RALA →	-0.697	-2.049	<.001	<.001	3	5
BREAST	DNMBP →	-0.767	-0.542	.006	.009	3	4
OVARY	HIVEP2 →	-0.871	-0.913	.003	.001	3	4
BREAST	UACA →	-1.285	-0.988	.002	.001	3	4
UPPER_AERODIGESTIVE_TRACT	PSD3 →	-1.319	-0.992	.004	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ACO1 by Aldehyde catabolic process activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →