Aldehyde catabolic process

Across TCGA cell cohorts, RNA activity of the Aldehyde catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PDLIM7, VSIR, and CES3, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Aldehyde catabolic process activity versus PDLIM7 in BONE (Pearson r = -0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	PDLIM7 →	-1.705	-0.439	.003	.008	3	7
BREAST	VSIR →	-2.090	-0.323	.001	.003	3	6
SOFT_TISSUE	CES3 →	+1.097	+0.366	.002	.002	2	7
BLOOD_Leukemia	DYSF →	-2.352	-0.224	<.001	<.001	3	5
LARGE_INTESTINE	MPC2 →	+1.117	+0.324	.008	.002	3	5
STOMACH	CRACD →	+2.214	+0.403	.001	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046185 vs PDLIM7 — BONE

Explore this scatter interactively →