Polyol catabolic process

Across TCGA patient cohorts, RNA activity of the Polyol catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TKFC, SORD, and ATR_S435, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Polyol catabolic process activity versus TKFC in BRCA (Pearson r = 0.40).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TKFC →	+0.309	+0.042	<.001	<.001	3	8
LSCC	SORD →	+0.572	+0.104	<.001	<.001	3	8
BRCA	ATR_S435 →	+0.442	+0.068	<.001	<.001	3	5
BRCA	COASY →	+0.330	+0.054	<.001	<.001	3	5
COAD	DPYSL2 →	-0.248	-0.037	.001	<.001	3	5
HNSC	KCTD12_S217 →	-0.385	-0.083	.009	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046174 vs TKFC — BRCA

Explore this scatter interactively →