Polyol catabolic process

Across TCGA patient cohorts, RNA activity of the Polyol catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CLIC5, ZBTB20-AS4, and MECOM, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Polyol catabolic process activity versus CLIC5 in CCRCC (Pearson r = 0.36).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	CLIC5 →	+0.917	+0.130	<.001	.003	3	4
HNSC	ZBTB20-AS4 →	+0.692	+0.077	<.001	.001	3	4
CCRCC	MECOM →	+0.611	+0.140	<.001	<.001	3	4
HNSC	ZNF14 →	+0.580	+0.077	.005	.007	3	3
BRCA	MDH1B →	+0.699	+0.109	.004	.004	3	3
BRCA	WDR31 →	+0.567	+0.113	.003	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046174 vs CLIC5 — CCRCC

Explore this scatter interactively →