Tetrahydrobiopterin metabolic process

Across TCGA patient cohorts, RNA activity of the Tetrahydrobiopterin metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the THYM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LRP1, MFAP2, and PCBD2, each associated with the pathway in up to 23 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Tetrahydrobiopterin metabolic process activity versus LRP1 in THYM (Pearson r = 0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
THYM	LRP1 →	-0.931	-0.020	.003	.001	1	23
UCS	MFAP2 →	-1.943	-0.050	.001	.002	2	21
UVM	PCBD2 →	+0.495	+0.025	<.001	<.001	2	20
READ	MRPS36 →	+0.449	+0.024	.002	<.001	2	20
GBM	UQCRQ →	+0.616	+0.036	<.001	<.001	3	18
MESO	COX7B →	+0.495	+0.026	<.001	.005	1	20

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046146 vs LRP1 — THYM

Explore this scatter interactively →