Pyrimidine nucleoside biosynthetic process

Across TCGA patient cohorts, RNA activity of the Pyrimidine nucleoside biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CAPN2, TK2, and CHAF1B, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pyrimidine nucleoside biosynthetic process activity versus CAPN2 in OV (Pearson r = 0.42).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	CAPN2 →	+0.607	+0.047	<.001	.001	3	6
LUAD	TK2 →	+0.465	+0.064	<.001	<.001	3	6
BRCA	CHAF1B →	-0.414	-0.040	.001	<.001	3	6
LUAD	ZC3H14_S620 →	-0.673	-0.042	.002	.001	3	6
BRCA	POLR1B →	-0.405	-0.046	<.001	<.001	3	6
CCRCC	USP36 →	-0.289	-0.049	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046134 vs CAPN2 — OV

Explore this scatter interactively →