Pyrimidine nucleoside biosynthetic process

Across TCGA pan-cancer cohorts, RNA activity of the Pyrimidine nucleoside biosynthetic process pathway is associated with patient survival in 19 of 34 cancer lineages. Pathway activity is summarized from the expression of its 5 member genes.

The strongest signal is observed in kidney chromophobe (KICH), where higher Pyrimidine nucleoside biosynthetic process pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as BRCA and SARC, show the opposite pattern, with higher activity associated with better survival.

KICH, BRCA, and LGG are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	DFS	Tertile	All	0.661	1.000	.012	53	view →
BRCA	DFS	Quartile	All	0.934	0.875	.008	52	view →
LGG	OS	Median	All	0.711	0.898	<.001	51	view →
ACC	OS	Median	II,III,IV	0.648	0.842	.012	41	view →
SARC	DFS	Tertile	All	0.640	0.404	<.001	32	view →
KIRC	DFS	Quartile	All	0.759	0.475	.005	30	view →
PAAD	DFS	Quartile	All	0.160	0.503	<.001	29	view →
KIRP	OS	Tertile	All	0.874	0.660	.004	25	view →
LAML	DFS	Quartile	All	0.210	0.622	.001	24	view →
LUSC	DFS	Median	III,IV	0.211	0.803	.001	19	view →
READ	DFS	Median	III,IV	0.584	0.873	.006	16	view →
STAD	DFS	Quartile	All	0.219	0.562	.007	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

GO:0046134–KICH (DFS)

Open the KICH breakdown →