Pyrimidine nucleoside biosynthetic process

Across TCGA cell cohorts, RNA activity of the Pyrimidine nucleoside biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UCKL1, CAD, and RTEL1, each associated with the pathway in up to 17 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pyrimidine nucleoside biosynthetic process activity versus UCKL1 in LUNG_NSCLC_LUSC (Pearson r = 0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	UCKL1 →	+1.025	+0.150	<.001	<.001	3	17
BONE	CAD →	+1.259	+0.116	<.001	.003	3	15
SKIN	RTEL1 →	+1.324	+0.153	<.001	<.001	3	14
BONE	MRGBP →	+1.000	+0.141	<.001	.002	3	12
URINARY_TRACT	C20orf27 →	+1.196	+0.131	.004	<.001	3	11
BLOOD_Lymphoma	RGS19 →	+1.173	+0.141	.003	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046134 vs UCKL1 — LUNG_NSCLC_LUSC

Explore this scatter interactively →