Pyrimidine nucleoside biosynthetic process

Across TCGA cell cohorts, RNA activity of the Pyrimidine nucleoside biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CBX1, DBF4B, and RUVBL1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pyrimidine nucleoside biosynthetic process activity versus CBX1 in PANCREAS (Pearson r = 0.60).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	CBX1 →	+1.074	+1.274	.005	.003	3	6
PANCREAS	DBF4B →	+0.785	+1.050	.007	.007	2	7
PANCREAS	RUVBL1 →	+0.897	+0.692	.001	.009	3	6
LIVER	CAD →	+1.383	+0.643	<.001	<.001	3	6
BONE	HDGFL2 →	+0.730	+0.450	.003	.001	3	6
STOMACH	RPS2 →	+1.247	+0.469	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046134 vs CBX1 — PANCREAS

Explore this scatter interactively →