Purine ribonucleoside catabolic process

Across TCGA patient cohorts, RNA activity of the Purine ribonucleoside catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are LCP2, WIPF1, and HCLS1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Purine ribonucleoside catabolic process activity versus LCP2 in HNSC (Pearson r = 0.41).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	LCP2 →	+0.405	+0.067	<.001	.001	3	7
HNSC	WIPF1 →	+0.336	+0.068	<.001	<.001	3	7
GBM	HCLS1 →	+0.547	+0.075	<.001	<.001	3	7
GBM	SIPA1 →	+0.217	+0.058	<.001	<.001	3	6
GBM	WAS →	+0.403	+0.070	<.001	<.001	3	6
GBM	ELMO1 →	+0.394	+0.069	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046130 vs LCP2 — HNSC

Explore this scatter interactively →