Purine ribonucleoside catabolic process

Across TCGA cell cohorts, RNA activity of the Purine ribonucleoside catabolic process pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ATP6V1C2, ANXA11, and CUBN, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ATP6V1C2 grouped by Purine ribonucleoside catabolic process-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	ATP6V1C2 →	+0.275	+1.753	.003	<.001	3	3
LUNG_NSCLC_LUAD	ANXA11 →	+0.138	+1.529	.004	.002	3	3
LARGE_INTESTINE	CUBN →	+0.254	+1.343	.007	.002	3	2
LARGE_INTESTINE	MDM1 →	-0.223	-1.792	.001	<.001	3	2
LARGE_INTESTINE	PSG8 →	-0.250	-1.375	<.001	.001	3	2
LARGE_INTESTINE	ALDH3B2 →	+0.066	+1.553	.003	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ATP6V1C2 by Purine ribonucleoside catabolic process activity — BREAST

Explore this box plot interactively →