Purine ribonucleoside catabolic process

Across TCGA cell cohorts, RNA activity of the Purine ribonucleoside catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MARVELD1, PRF1, and SLC30A4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Purine ribonucleoside catabolic process activity versus MARVELD1 in LUNG_NSCLC_LUAD (Pearson r = -0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	MARVELD1 →	-1.371	-1.524	<.001	<.001	3	3
LUNG_NSCLC_LUAD	PRF1 →	+0.041	+1.444	.002	.001	3	3
LARGE_INTESTINE	SLC30A4 →	-0.608	-1.685	<.001	<.001	3	3
LARGE_INTESTINE	LHFPL2 →	-0.780	-1.162	.005	.006	3	3
LARGE_INTESTINE	MED30 →	+0.861	+1.795	.003	<.001	3	3
LARGE_INTESTINE	C9orf152 →	+2.478	+1.332	.008	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046130 vs MARVELD1 — LUNG_NSCLC_LUAD

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