Inosine metabolic process

Across TCGA patient cohorts, RNA activity of the Inosine metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are XDH, ATAD2, and PRIM1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Inosine metabolic process activity versus XDH in UCEC (Pearson r = 0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	XDH →	+1.698	+0.157	<.001	.008	3	7
LSCC	ATAD2 →	-0.712	-0.125	<.001	.001	3	6
LSCC	PRIM1 →	-0.660	-0.141	<.001	<.001	3	6
GBM	NCAPG →	-0.661	-0.076	.004	.002	3	5
HNSC	RAD51AP1 →	-0.906	-0.148	<.001	<.001	3	5
LSCC	SMC4 →	-0.728	-0.138	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046102 vs XDH — UCEC

Explore this scatter interactively →