Guanine metabolic process

Across TCGA cell cohorts, RNA activity of the Guanine metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AKR1C3, KCNT1, and CYP2E1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Guanine metabolic process activity versus AKR1C3 in STOMACH (Pearson r = 0.84).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	AKR1C3 →	+5.960	+2.007	<.001	<.001	3	3
OESOPHAGUS	KCNT1 →	+1.749	+1.717	.009	<.001	3	2
OESOPHAGUS	CYP2E1 →	+1.490	+1.717	<.001	<.001	3	2
OESOPHAGUS	RBMX2 →	+0.960	+1.717	.007	<.001	3	2
OESOPHAGUS	STAT4 →	-1.039	-1.975	.002	.006	3	2
OESOPHAGUS	GTF3C5 →	+0.834	+1.717	.009	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046098 vs AKR1C3 — STOMACH

Explore this scatter interactively →