DUMP catabolic process

Across TCGA patient cohorts, RNA activity of the DUMP catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are UPP1, AHNAK2_S260, and S100A16, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, DUMP catabolic process activity versus UPP1 in LUAD (Pearson r = 0.24).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	UPP1 →	+0.564	+0.075	.001	.001	3	7
LUAD	AHNAK2_S260 →	+1.504	+0.075	<.001	<.001	3	6
LSCC	S100A16 →	+0.642	+0.092	.002	<.001	3	6
LSCC	AHNAK2 →	+1.110	+0.111	<.001	<.001	3	5
LSCC	KRT14 →	+1.312	+0.065	<.001	.005	3	5
OV	AHNAK2_S4419 →	+1.374	+0.069	.004	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046079 vs UPP1 — LUAD

Explore this scatter interactively →