DUMP catabolic process

Across TCGA patient cohorts, RNA activity of the DUMP catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRKAR1B-AS1, UPP1, and IL21R, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, DUMP catabolic process activity versus PRKAR1B-AS1 in OV (Pearson r = 0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	PRKAR1B-AS1 →	+0.750	+0.164	<.001	<.001	3	7
LSCC	UPP1 →	+0.832	+0.116	.002	.003	3	7
GBM	IL21R →	+0.813	+0.116	<.001	.001	3	6
OV	BTK →	+0.631	+0.121	.004	.002	3	6
COAD	FLI1 →	+0.672	+0.182	<.001	<.001	3	6
LSCC	C3AR1 →	+0.923	+0.150	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046079 vs PRKAR1B-AS1 — OV

Explore this scatter interactively →