DUMP catabolic process

Across TCGA cell cohorts, RNA activity of the DUMP catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are POLR3H, EIF2S1, and EIF2B5, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, POLR3H grouped by DUMP catabolic process-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	POLR3H →	+0.862	+0.902	<.001	<.001	3	4
CNS	EIF2S1 →	+1.092	+1.122	.001	<.001	3	4
CNS	EIF2B5 →	+0.378	+0.939	<.001	.003	3	4
BLOOD_Leukemia	TGFBR2 →	+1.155	+1.255	.002	<.001	3	4
LUNG_NSCLC_LUAD	MRGBP →	+0.686	+0.765	<.001	.008	3	4
LUNG_SCLC	HMGN1 →	-0.732	-0.627	.002	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

POLR3H by DUMP catabolic process activity — CNS

Explore this box plot interactively →