DUMP catabolic process

Across TCGA cell cohorts, RNA activity of the DUMP catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RNASEL, HPCAL1, and RASA1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, DUMP catabolic process activity versus RNASEL in SOFT_TISSUE (Pearson r = -0.82).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	RNASEL →	-1.457	-1.836	<.001	<.001	3	5
OVARY	HPCAL1 →	-1.756	-1.613	.004	<.001	2	6
CNS	RASA1 →	-0.905	-0.967	.003	<.001	3	4
BLOOD_Leukemia	MEAK7 →	-1.472	-1.099	.001	.002	3	4
LARGE_INTESTINE	MVD →	-0.984	-0.976	<.001	.001	3	4
SKIN	PCYOX1L →	-0.968	-0.303	.008	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046079 vs RNASEL — SOFT_TISSUE

Explore this scatter interactively →