DUMP metabolic process

Across TCGA patient cohorts, RNA activity of the DUMP metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are UPP1, SNX17, and TRIM24_S811, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, DUMP metabolic process activity versus UPP1 in UCEC (Pearson r = 0.28).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	UPP1 →	+0.517	+0.133	.004	.002	1	7
COAD	SNX17 →	+0.233	+0.057	<.001	.001	3	5
COAD	TRIM24_S811 →	-0.270	-0.040	<.001	.001	3	5
LSCC	AHNAK2 →	+0.968	+0.097	<.001	<.001	3	5
HNSC	AHNAK2_S5175 →	+0.814	+0.113	<.001	<.001	3	5
LSCC	AHNAK2_S260 →	+1.164	+0.058	<.001	.006	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046078 vs UPP1 — UCEC

Explore this scatter interactively →