DUMP metabolic process

Across TCGA patient cohorts, RNA activity of the DUMP metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FAM20A, P2RY6, and IL21R, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, DUMP metabolic process activity versus FAM20A in HNSC (Pearson r = 0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	FAM20A →	+0.645	+0.137	.003	<.001	3	7
UCEC	P2RY6 →	+0.821	+0.179	.002	.001	3	7
GBM	IL21R →	+0.780	+0.078	<.001	.005	3	7
HNSC	CYTH4 →	+1.371	+0.180	<.001	<.001	3	6
HNSC	ATP8B4 →	+0.635	+0.136	<.001	<.001	3	6
GBM	FCGR1B →	+0.471	+0.112	.003	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046078 vs FAM20A — HNSC

Explore this scatter interactively →