DUMP metabolic process

Across TCGA cell cohorts, RNA activity of the DUMP metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DHX30, SCAP, and QRICH1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, DUMP metabolic process activity versus DHX30 in KIDNEY (Pearson r = 0.75).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	DHX30 →	+0.811	+1.064	.001	.009	3	5
LUNG_SCLC	SCAP →	+0.586	+0.149	.001	<.001	3	4
KIDNEY	QRICH1 →	+0.995	+1.064	.003	.009	3	4
LUNG_SCLC	RBM15B →	+0.906	+0.261	<.001	<.001	3	4
LUNG_SCLC	IP6K2 →	+0.544	+0.136	.001	.001	3	4
SOFT_TISSUE	BCL9 →	+1.339	+0.331	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046078 vs DHX30 — KIDNEY

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