DTTP metabolic process

Across TCGA patient cohorts, RNA activity of the DTTP metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RRM2, SMC2, and SMC4, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, DTTP metabolic process activity versus RRM2 in OV (Pearson r = 0.49).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	RRM2 →	+0.774	+0.096	<.001	<.001	3	9
GBM	SMC2 →	+0.645	+0.068	.001	<.001	3	9
OV	SMC4 →	+0.544	+0.080	<.001	<.001	3	9
LUAD	MCM2 →	+0.579	+0.059	<.001	<.001	3	9
OV	MCM3 →	+0.649	+0.064	<.001	<.001	3	9
LUAD	MCM4 →	+0.599	+0.062	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046075 vs RRM2 — OV

Explore this scatter interactively →