DTMP metabolic process

Across TCGA cell cohorts, RNA activity of the DTMP metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TLE2, PPIC, and TBC1D2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, DTMP metabolic process activity versus TLE2 in BONE (Pearson r = 0.63).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	TLE2 →	+4.675	+1.663	<.001	.001	3	6
BONE	PPIC →	-3.367	-1.360	.006	.002	2	6
BONE	TBC1D2 →	-2.476	-1.715	.002	.001	3	5
SKIN	MYBL2 →	+0.882	+1.179	.005	.005	3	5
BLOOD_Leukemia	TCF3 →	+0.938	+0.346	<.001	<.001	3	5
KIDNEY	SHPRH →	+0.763	+1.403	.006	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046073 vs TLE2 — BONE

Explore this scatter interactively →