DTMP metabolic process

Across TCGA cell cohorts, RNA activity of the DTMP metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DUT, TK1, and RRM2, each associated with the pathway in up to 15 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, DTMP metabolic process activity versus DUT in STOMACH (Pearson r = 0.66).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	DUT →	+1.948	+1.336	.002	.001	3	15
PANCREAS	TK1 →	+1.518	+1.509	.001	<.001	3	13
PANCREAS	RRM2 →	+2.488	+1.292	<.001	<.001	3	13
STOMACH	TRMT112 →	+1.270	+1.660	.002	<.001	3	12
LUNG_NSCLC_LUSC	CCT4 →	+1.453	+1.725	.001	<.001	3	12
LUNG_NSCLC_LUSC	RAN →	+1.227	+1.760	.004	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046073 vs DUT — STOMACH

Explore this scatter interactively →