UTP metabolic process

Across TCGA patient cohorts, RNA activity of the UTP metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NME7, TTC21B, and IFT52, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, UTP metabolic process activity versus NME7 in LSCC (Pearson r = 0.47).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	NME7 →	+0.306	+0.051	<.001	<.001	3	6
UCEC	TTC21B →	+0.285	+0.084	<.001	<.001	3	5
BRCA	IFT52 →	+0.336	+0.046	<.001	<.001	3	5
UCEC	IFT88 →	+0.575	+0.113	<.001	<.001	3	5
UCEC	ARL6 →	+0.269	+0.068	.002	.001	3	5
GBM	CFAP36 →	+0.314	+0.077	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0046051 vs NME7 — LSCC

Explore this scatter interactively →